Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oxidative stress and autophagy.

Roberta Kiffin1, Urmi Bandyopadhyay, Ana Maria Cuervo

  • 1Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Antioxidants & Redox Signaling
|February 21, 2006
PubMed
Summary

Organisms combat oxidative stress by increasing antioxidants and clearing damaged parts. While lysosomes can be damaged by oxidative stress, they also play a protective role in clearing cellular components via autophagy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chaperone-mediated autophagy is a tumor-suppressive mechanism in hepatocellular carcinoma.

Cell reports·2026
Same author

Chaperone-mediated autophagy is required for regulatory T cell function.

Nature communications·2026
Same author

Peptide-mediated inhibition of aberrant chaperone-mediated autophagy in pericytes prevents glioblastoma progression through MAPT/tau secretion.

Autophagy·2026
Same author

Chaperone-mediated autophagy protects against retinal photoreceptor degeneration by modulating proteostasis of glucose metabolism enzymes.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Toward actionable interventions in human aging (12th ARDD meeting, 2025).

Aging·2026
Same author

Chaperone-mediated autophagy: the Achilles heel of the retinal pigment epithelium during age-related macular degeneration.

Autophagy·2026

Area of Science:

  • Cellular Biology
  • Oxidative Stress Response

Background:

  • Oxidative injury triggers cellular defense mechanisms, including antioxidant production and removal of damaged components.
  • Lysosomes are traditionally viewed as targets of reactive oxygen species, with membrane destabilization leading to cellular damage.
  • Emerging evidence suggests a protective function for lysosomes in early oxidative injury through autophagy.

Purpose of the Study:

  • To review the dual role of the lysosomal system in response to oxidative stress.
  • To discuss the interplay between lysosomal function and other cellular proteolytic systems.

Main Methods:

  • Literature review of studies investigating oxidative stress and cellular responses.
  • Analysis of the mechanisms involved in lysosomal membrane integrity and function under oxidative conditions.

Related Experiment Videos

  • Examination of the activation of ubiquitin/proteasome and lysosomal/autophagic pathways.

    • Main Results:

    • Oxidative stress prompts an increase in intracellular antioxidants and removal of damaged components.
    • Lysosomal membrane destabilization by reactive oxygen species can cause cellular damage.
    • Lysosomes contribute to cellular protection by degrading altered components via autophagy during early oxidative injury.

    Conclusions:

    • The lysosomal system exhibits opposing roles in oxidative stress: it can be a source of damage but also a crucial protective mechanism.
    • Activation of both the ubiquitin/proteasome and lysosomal/autophagic systems is a key feature of the oxidative stress response.
    • Understanding the complex role of lysosomes is vital for comprehending cellular adaptation to oxidative injury.