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Related Concept Videos

Aging01:26

Aging

1.0K
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
1.0K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

4.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
327
Mitochondria01:37

Mitochondria

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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

358
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Techniques to Induce and Quantify Cellular Senescence
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Toward actionable interventions in human aging (12th ARDD meeting, 2025).

Aleksandr Dekan1, Sierra Lore1,2, Ye Eun Yoon1

  • 1Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.

Aging
|April 7, 2026
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Summary

Aging research is shifting towards personalized therapies by understanding aging mechanisms. This approach aims to extend human healthspan by targeting specific molecular pathways, moving beyond damage accumulation theories.

Keywords:
agingbiomarkersgerosciencelongevityrejuvenation

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Area of Science:

  • Gerontology
  • Biomedical Engineering
  • Pharmacology

Background:

  • The 12th Aging Research and Drug Discovery (ARDD) meeting highlighted a paradigm shift in aging research.
  • The field is moving from correlational studies to mechanistic understandings for therapeutic development.

Purpose of the Study:

  • To summarize key research directions and conceptual frameworks presented at the ARDD meeting.
  • To highlight the integration of interdisciplinary approaches in aging research.

Main Methods:

  • Discussions integrated fundamental biology with artificial intelligence (AI) and machine learning (ML) for drug discovery.
  • Novel preclinical research models were presented to enhance translational studies.

Main Results:

  • Advancements focus on identifying and modulating specific molecular mechanisms regulating aging.
  • The hypothesis that aging is a modifiable biological process amenable to intervention was emphasized.

Conclusions:

  • Personalized therapeutic interventions targeting aging mechanisms are becoming feasible.
  • Interdisciplinary collaboration and advanced models are crucial for extending human healthspan.