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Updated: Aug 11, 2026

Evaluation of Motor Impairment in C. elegans Models of Amyotrophic Lateral Sclerosis
Published on: September 2, 2021
Wheelchair economy class syndrome in amyotrophic lateral sclerosis
Fumiharu Kimura1, Simon Ishida, Daisuke Furutama
1Division of Neurology, The First Department of Internal Medicine, Osaka Medical College, Daigaku-machi 2-7, Takatsukishi, Osaka 569-8686, Japan. in1110@poh.osaka-med.ac.jp
Abstract:
A wheelchair-bound 61-year-old diabetic man with amyotrophic lateral sclerosis (ALS) developed sudden respiratory failure. Specific findings for hypoxemia and hypocapnia were incompatible with type II respiratory failure seen in the terminal stages of ALS. 'Economy class syndrome' was diagnosed, with massive thrombosis in the pulmonary arteries and deep vein thrombosis. This case offers a warning for long-term wheelchair users, particularly hypoxemic ALS patients, regarding the risks of treatable pulmonary thromboembolism.
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