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Updated: Aug 11, 2026

Detection and Quantification of Calcitonin Gene-Related Peptide (CGRP) in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay
Published on: June 16, 2023
[Analytical interference in determination of procalcitonin by PCT-Q (Brahms)]
C Désidéri-Vaillant1, Y Rouby, N Cardon
1Fédération de biologie clinique, HIA Clermont-Tonnerre 29240 Brest-Armées, France. biochimie@hopital-armees-brest.fr
Abstract:
Procalcitonin (PCT) is a biological marker of infection. We present the cas of a patient who has presented a high concentration of PCT with PCT-Q test (Brahms). At the same time, the concentration of CRP is remained low, which is no physiological. Then, PCT concentration has been determinated with an automatic system (Kryptor-Brahms) and finded at low than 0.5 microg/l. Brahms company has searched an analytical interference: human anti-mouse antibodies (HAMA) were positive. If PCT concentration stay a marker of infection for the most part, this case show that biologists have to keep in mind that immunological assays remain submitted to interferences.
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