Insulin resistance syndrome and polycystic ovary syndrome: implications for diagnosis and treatment
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Updated: Aug 11, 2026

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
Published on: March 5, 2022
1Division of Endocrinology, Department of Medicine, University Hospital of Essen Medical School, Essen, Germany.
Abstract:
Both insulin resistance syndrome (IRS) and polycystic ovary syndrome (PCOS) are common endocrinopathies. IRS, usually associated with ages of 50+, type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD), is highly prevalent in young PCOS patients, exceeding the expected rate from their prevailing obesity. While it is clear that women with PCOS cluster risk factors, prospective studies to prove a higher morbidity and mortality from T2DM and CVD are not available. Nevertheless, apart from cosmetic concerns and gynecological problems, therapeutic intervention should also be designed to reduce the metabolic risk of PCOS, which may well be the main determinant of long-term health in affected women.
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