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Adenocarcinoma of the vermiform appendix. A population study
G P Nielsen1, H J Isaksson, H Finnbogason
1Department of Pathology, University of Iceland, Reykjavik.
Summary
This study reviewed seven cases of appendiceal adenocarcinoma in Iceland. Early diagnosis and surgical resection improved patient survival for this rare cancer.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Adenocarcinoma of the vermiform appendix is a rare malignancy.
- This study examines cases from Iceland between 1974 and 1989.
Purpose of the Study:
- To report on the incidence, clinical presentation, and outcomes of appendiceal adenocarcinoma.
- To analyze diagnostic challenges and survival rates.
Main Methods:
- Retrospective case series analysis of seven patients diagnosed with adenocarcinoma of the vermiform appendix.
- Review of clinical records, surgical findings, and pathological reports.
Main Results:
- Seven cases identified over 16 years, with an approximate incidence of 0.2 cases/100,000/year.
- Patients aged 25-83 years; five males, two females. Five mucinous, two non-mucinous adenocarcinoma.
- Four presented with acute appendicitis symptoms; three had long-term survival post-resection. Three presented with metastatic disease, with poor survival.
Conclusions:
- Appendiceal adenocarcinoma diagnosis is often delayed, with preoperative diagnosis being rare.
- Surgical resection is crucial for potentially curative treatment in resectable cases.
- Further research is needed to improve early detection and management strategies.