Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An evolutionary perspective on the photoreceptor damage response.

Amir Rattner1, Jeremy Nathans

  • 1Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

American Journal of Ophthalmology
|February 24, 2006
PubMed
Summary

Recent advances reveal the retina's photoreceptor damage response may have evolved to protect against retinal tears, infections, and light damage. Understanding this natural defense could lead to new treatments for photoreceptor diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enhancers that direct gene expression to central nervous system vascular endothelial cells in vivo.

Neuron·2026
Same author

Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation.

eLife·2025
Same author

Utility of protein-protein binding surfaces composed of anti-parallel alpha-helices and beta-sheets selected by phage display.

The Journal of biological chemistry·2024
Same author

Normal and Sjogren's syndrome models of the murine lacrimal gland studied at single-cell resolution.

Proceedings of the National Academy of Sciences of the United States of America·2023
Same author

Seeing is believing: The development of optical coherence tomography.

Proceedings of the National Academy of Sciences of the United States of America·2023
Same author

Bacterial meningitis in the early postnatal mouse studied at single-cell resolution.

eLife·2023

Area of Science:

  • Ophthalmology
  • Evolutionary Biology
  • Retinal Research

Background:

  • Significant progress has been made in understanding the molecular and cellular mechanisms underlying the retina's response to photoreceptor damage.
  • The evolutionary context of this response remains an area of active investigation.

Purpose of the Study:

  • To review recent scientific advancements concerning the photoreceptor damage response.
  • To analyze the evolutionary pressures that have shaped this biological mechanism.

Main Methods:

  • Synthesis of existing data from laboratory studies, clinical trials, and epidemiological research.
  • Analysis of published findings on the mechanism and function of the photoreceptor damage response.

Main Results:

Related Experiment Videos

  • The study suggests the photoreceptor damage response may have evolved as a protective mechanism against conditions such as retinal tears, detachment, infectious retinitis, and light-induced damage.
  • Advances in understanding the molecular and cellular basis of this response have been considerable in recent years.

Conclusions:

  • Fully defining the natural response to photoreceptor damage is crucial for therapeutic development.
  • Potential exists to modulate beneficial or detrimental aspects of the damage response for treating various photoreceptor diseases.