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Updated: Aug 11, 2026

Synthesis of a Water-soluble Metal–Organic Complex Array
Published on: October 8, 2016
Synthesis of polymetallic macrocyclic terpene-derived hybrids
Elsa Alvaro1, María C de la Torre, Miguel A Sierra
1Instituto de Química Orgánica, Consejo Superior de Investigaciones Científicas, Juan de la Cierva 3, 28006 Madrid, Spain.
Terpene alkyne systems are versatile templates for creating complex natural product hybrids and macrocyclic structures. The Nicholas reaction is key to assembling these intricate molecules with multiple terpene units and cobalt atoms.
Area of Science:
- Organic Chemistry
- Natural Product Synthesis
- Organometallic Chemistry
Background:
- Terpene alkyne systems are valuable building blocks in organic synthesis.
- The Nicholas reaction is a powerful tool for carbon-carbon bond formation.
Purpose of the Study:
- To explore the utility of terpene alkyne systems as templates.
- To synthesize complex natural product hybrids and macrocyclic structures.
Main Methods:
- Utilizing terpene alkyne systems as synthetic templates.
- Employing the Nicholas reaction for C-C bond formation.
- Assembling macrocyclic structures with multiple terpene units.
Main Results:
- Successfully prepared natural product hybrids using terpene alkyne templates.
- Synthesized macrocyclic structures containing up to four terpene units.
- Incorporated up to eight cobalt atoms into the macrocyclic frameworks.
Conclusions:
- Terpene alkyne systems are effective templates for complex molecule synthesis.
- The Nicholas reaction enables the construction of intricate macrocyclic architectures.
- This methodology facilitates the creation of novel natural product-inspired compounds.
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