Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effects on plasma glucose and lactate.

Andrew Young1

  • 1Amylin Pharmaceuticals, Inc., San Diego, California, USA.

Advances in Pharmacology (San Diego, Calif.)
|February 24, 2006
PubMed
Summary

Amylin agonists increase plasma lactate and glucose in rodents, a response useful for identifying these agents. These glycemic effects, distinct from glucose-lowering actions, involve skeletal muscle and differ between species and feeding states.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Remote sensing data and machine learning models estimate sorghum grain yield in a plant breeding program.

Plant phenomics (Washington, D.C.)·2026
Same author

Safety, immunogenicity, and dose ranging of a bivalent respiratory syncytial virus and human metapneumovirus glycoprotein F-molecular clamp vaccine candidate in older adults: 1-month interim analysis of an ongoing randomised, observer-blind, placebo- and active-controlled, phase 1 trial.

Vaccine·2026
Same author

Stepwise loss of complexity in hagfish eyes prior to deep sea colonization.

Biology letters·2026
Same author

Viral mimicry redirects immunosuppressed colorectal tumour landscapes towards a proinflammatory and CMS1-like regenerative state.

Communications biology·2026
Same author

Physiological and Yield Responses of Peanut (<i>Arachis hypogaea</i> L.) Genotypes Under Well-Watered and Water-Stressed Conditions.

Plants (Basel, Switzerland)·2026
Same author

Nerve Combing for Idiopathic Trigeminal Neuralgia Without Neurovascular Compression.

Journal of clinical and experimental dentistry·2026

Area of Science:

  • Endocrinology and Metabolism
  • Pharmacology

Background:

  • Amylin and its agonists are investigated for their metabolic effects.
  • Species-specific responses to amylin agonists, including plasma lactate and glucose changes, have been observed.

Purpose of the Study:

  • To explore the utility of amylin-induced plasma lactate and glucose increases in identifying amylin agonists (amylinomimetic agents).
  • To differentiate between glycemic and glucose-lowering effects of amylin agonists across species and physiological states.

Main Methods:

  • Administration of amylin and various amylin agonists (pramlintide, salmon calcitonin, CGRP) to non-diabetic fasting rats and mice.
  • Measurement of plasma lactate and glucose levels.
  • Comparison of observed effects with those seen during exercise, adrenergic stimulation, and lactic acidosis.

Main Results:

  • Injection of amylin or its agonists increased plasma lactate and glucose in fasting rodents.
  • These glycemic effects are species-dependent, with less pronounced increases in humans.
  • Lactate originates from skeletal muscle, unlike in lactic acidosis.
  • Glycemic effects are prominent in the fasted state, while glucose-lowering effects are more pronounced postprandially and occur in all studied species.

Conclusions:

  • The increase in plasma lactate and glucose serves as a marker for identifying amylin agonists.
  • Glycemic and glucose-lowering effects of amylin agonists are mechanistically and physiologically distinct, varying by species and feeding status.
  • The Cori cycle may play a role in the observed substrate fluxes related to amylin action.

Related Experiment Videos