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Therapeutic hypothermia following perinatal asphyxia
1Division of Clinical Sciences, Faculty of Medicine, Imperial College London, UK. David.Edwards@imperial.ac.uk
Archives of Disease in Childhood. Fetal and Neonatal Edition
|February 24, 2006
Summary
Hypothermic neural rescue therapy, using selective head or total body cooling, shows promise in reducing death or disability in infants with neonatal encephalopathy after birth asphyxia. Further research is needed to establish cooling as standard care.
Area of Science:
- Neonatal medicine
- Therapeutic hypothermia
Background:
- Neonatal encephalopathy is a serious condition in newborns.
- Birth asphyxia can lead to significant neurological damage.
- Hypothermic neural rescue therapy is an emerging treatment.
Purpose of the Study:
- To evaluate the effectiveness of hypothermic neural rescue therapy.
- To assess the impact of cooling on infant outcomes after birth asphyxia.
Main Methods:
- Analysis of well-constructed clinical trials.
- Inclusion of data from selective head cooling and total body cooling therapies.
Main Results:
- Therapeutic hypothermia (selective head or total body cooling) reduces the combined risk of death or disability.
- Evidence suggests a positive impact of cooling on infant outcomes.
Conclusions:
- Hypothermic neural rescue therapy is a promising intervention for neonatal encephalopathy.
- More data may be required before widespread adoption as standard care.
