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[Stopping smoking and constipation].

Gilbert Lagrue¹, Solange Cormier, Catherine Mautrait

¹Hôpital Albert Chenevier, Créteil. gilbert.lagrue@ach.ap-hop-paris.fr

Presse Medicale (Paris, France : 1983)

|February 24, 2006

Summary

Constipation is a common but understudied symptom of smoking withdrawal, particularly affecting women. Nicotine

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Area of Science:

Gastroenterology
Addiction Medicine
Pharmacology

Background:

Smoking cessation often leads to various withdrawal symptoms.
Constipation is a frequently reported, yet poorly understood, symptom of nicotine withdrawal.

Observation:

Three female participants experienced constipation upon smoking cessation.
Constipation symptoms improved with temporary smoking relapses.

Findings:

Nicotine withdrawal-induced constipation can cause significant functional gastrointestinal disorders.
This condition is more prevalent in women and individuals with a predisposition to constipation.
Nicotine stimulates intestinal peristalsis via the parasympathomimetic system, suggesting a self-medication effect of smoking.

Implications:

Recognizing and managing constipation is crucial for successful smoking cessation.
Magnesium salts are recommended as a first-line treatment.
Neostigmine offers an effective alternative for refractory cases, targeting the anticholinesterase pathway.

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