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Updated: Jul 22, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition
10:37

Induction and Analysis of Epithelial to Mesenchymal Transition

Published on: August 27, 2013

Complex networks orchestrate epithelial-mesenchymal transitions.

Jean Paul Thiery1, Jonathan P Sleeman

  • 1Centre National de la Recherche Scientifique (CNRS) Unité Mixte Recherche (UMR) 144 and Institut Curie, 26 rue d'Ulm, 75248 Paris Cedex 05, France. Jean-Paul.Thiery@curie.fr

Nature Reviews. Molecular Cell Biology
|February 24, 2006
PubMed
Summary

Epithelial-mesenchymal transition is crucial for forming tissues and organs during development. Understanding this process also sheds light on cancer progression and fibrosis.

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Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Cancer Research

Background:

  • Epithelial-mesenchymal transition (EMT) is essential for morphogenesis, enabling tissue and organ formation.
  • EMT involves epithelial cell plasticity and the generation of mesenchymal cells.
  • The mechanisms underlying EMT extend beyond cell-lineage segregation.

Purpose of the Study:

  • To elucidate the fundamental mechanisms by which epithelial cells transition to a mesenchymal state.
  • To explore the broader implications of EMT in developmental processes and disease.

Main Methods:

  • This study likely involves analyzing cellular and molecular changes during EMT.
  • Investigating signaling pathways that regulate epithelial cell plasticity.
  • Utilizing developmental models and potentially cancer cell lines.

Main Results:

  • Mesenchymal cells arise from an epithelial default state through specific biological processes.
  • EMT is a key factor in understanding developmental processes.
  • Insights into EMT can inform research on fibrosis and cancer.

Conclusions:

  • Understanding the origins of mesenchymal cells from epithelial precursors is vital.
  • EMT research has significant implications for developmental biology, fibrosis, and cancer progression.