Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Apparent bicarbonate space in children.

Horacio A Repetto1, Roberto Penna

  • 1Service of Pediatrics, Hospital Nacional Prof. A. Posadas, Buenos Aires, Argentina. harepetto@yahoo.com.ar

Thescientificworldjournal
|February 24, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Management of cirrhotic ascites in children: Review and recommendations. Part 2: Electrolyte disturbances, nonelectrolyte disturbances, therapeutic options.

Archivos argentinos de pediatria·2017
Same author

Management of cirrhotic ascites in children. Review and recommendations. Part 1: Pathophysiology, diagnostic evaluation, hospitalization criteria, treatment, nutritional management.

Archivos argentinos de pediatria·2017
Same author

Ouabain Protects Human Renal Cells against the Cytotoxic Effects of Shiga Toxin Type 2 and Subtilase Cytotoxin.

Toxins·2017
Same author

Effects of shiga toxin 2 on cellular regeneration mechanisms in primary and three-dimensional cultures of human renal tubular epithelial cells.

Microbial pathogenesis·2016
Same author

Prevention of renal damage caused by Shiga toxin type 2: Action of Miglustat on human endothelial and epithelial cells.

Toxicon : official journal of the International Society on Toxinology·2015
Same author

TLR4 genotype and environmental LPS mediate RSV bronchiolitis through Th2 polarization.

The Journal of clinical investigation·2015
Same journal

Solvent Extraction of Metals in the Circular Economy: Enhancing Resource Efficiency and Sustainability.

TheScientificWorldJournal·2026
Same journal

Agronomic Performance and Nutritive Value Evaluation of Desho Grass Varieties Under Supplementary Irrigation in Western Oromia, Ethiopia.

TheScientificWorldJournal·2026
Same journal

Physicians' and Hospital Administrators' Perspectives of Diagnosis-Related Groups (DRGs) in High-Income Countries: A Systematic Review.

TheScientificWorldJournal·2026
Same journal

The Eco-Friendly Preparation of Se, Zn, and Ag MONPs and Their Current Medical Applications and Drug Delivery for AD Diseases.

TheScientificWorldJournal·2026
Same journal

Fear of COVID-19: A Comparative Study Among University Students in Peru.

TheScientificWorldJournal·2026
Same journal

Opportunities and Challenges of Integrating Ethiopian Traditional Medicine System Into Modern Medicine: A Narrative Review.

TheScientificWorldJournal·2026
See all related articles

Bicarbonate infusion corrects metabolic acidosis, but its distribution volume varies due to buffer system interactions. This study explores bicarbonate space in children and adults to guide treatment.

Area of Science:

  • Physiology
  • Biochemistry
  • Pediatric Medicine

Background:

  • The volume of distribution is crucial for calculating solute concentration changes.
  • Unlike fixed-volume electrolytes, bicarbonate's distribution (bicarbonate space) is dynamic due to its role in blood buffer systems.
  • Bicarbonate infusion is a common treatment for hyperchloremic metabolic acidosis.

Purpose of the Study:

  • To review experimental evidence explaining the variable bicarbonate space.
  • To analyze the underlying hypotheses for bicarbonate's dynamic distribution.
  • To report on measured apparent bicarbonate space in pediatric patients and compare it with adult literature.

Main Methods:

  • Review of experimental studies on bicarbonate distribution.
  • Analysis of basic hypotheses for variable bicarbonate space.

Related Experiment Videos

  • Measurement of apparent bicarbonate space in pediatric patients with metabolic acidosis treated with bicarbonate infusion.
  • Comparison of pediatric data with existing adult literature.

    • Main Results:

    • Experimental studies support the concept of a variable bicarbonate space.
    • The participation of bicarbonate in blood buffer systems explains its non-fixed volume of distribution.
    • Apparent bicarbonate space was measured in pediatric patients and compared to adult data.

    Conclusions:

    • Bicarbonate's volume of distribution is not a fixed physical volume but is influenced by its buffering role.
    • This study provides insights into bicarbonate space in pediatric patients, addressing a gap in clinical research.
    • Guidelines for bicarbonate dosing based on baseline concentration are proposed.