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Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
Published on: February 14, 2022
[Negative-pressure pulmonary edema (NPPE)]
M Alb1, C Tsagogiorgas, J P Meinhardt
1Klink für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Mannheim. markus.alb@anaes.ma.uni-heidelberg.de
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS
|February 24, 2006
Summary
Negative-pressure pulmonary edema (NPPE), often caused by upper airway obstruction (UAO), requires prompt recognition and treatment by anesthesiologists. This condition presents as acute respiratory failure with specific symptoms, necessitating timely intervention.
Area of Science:
- Anesthesiology
- Pulmonary Medicine
- Critical Care
Context:
- Negative-pressure pulmonary edema (NPPE) is a perioperative complication.
- It is frequently associated with upper airway obstruction (UAO), such as laryngospasm.
- NPPE can occur in intubated and non-intubated patients, including those on supplemental oxygen.
Purpose:
- To highlight the clinical significance of NPPE in anesthesiology.
- To emphasize the mandatory early recognition and treatment of NPPE.
- To discuss the pathophysiology and presentation of NPPE.
Summary:
- NPPE is characterized by acute respiratory failure, dyspnea, tachypnea, and strained breathing.
- Pathophysiology involves extreme negative intrathoracic pressure during spontaneous ventilation, leading to fluid transudation.
- Symptoms include paradoxical ventilation, pink frothy sputum, stridor, and agitation.
Impact:
- Early identification and management by anesthesiologists are crucial for patient outcomes.
- Understanding NPPE incidence and prevalence is important, despite diagnostic variations.
- This knowledge aids in managing respiratory distress in perioperative settings.
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