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Related Experiment Videos

MusTRD can regulate postnatal fiber-specific expression.

Laura L Issa1, Stephen J Palmer, Kim L Guven

  • 1Muscle Development Unit, Children's Medical Research Institute, Wentworthville, NSW 2145, Australia.

Developmental Biology
|February 24, 2006
PubMed
Summary
This summary is machine-generated.

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Human MusTRD1alpha1 protein targets slow muscle fiber genes, causing their conversion to fast fibers in mice. This leads to muscle weakness, suggesting a common regulatory element in slow fiber genes.

Area of Science:

  • Muscle biology
  • Molecular genetics
  • Developmental biology

Background:

  • Human MusTRD1alpha1 binds the Troponin I slow upstream enhancer (TnIslow USE).
  • MusTRD1alpha1 was predicted to regulate slow fiber-specific genes.

Purpose of the Study:

  • To investigate the in vivo role of hMusTRD1alpha1 in skeletal muscle fiber type determination.
  • To test if hMusTRD1alpha1 can regulate slow fiber-specific genes.

Main Methods:

  • Generation of transgenic mice expressing hMusTRD1alpha1 in skeletal muscle.
  • Analysis of skeletal muscle fiber type composition and gene expression in adult and developing transgenic mice.

Main Results:

  • Adult transgenic mice exhibited a complete loss of slow muscle fibers, replaced by fast IIA fibers, causing postural weakness.

Related Experiment Videos

  • Postnatal, but not embryonic, expression of hMusTRD1alpha1 induced a gradual slow-to-fast fiber conversion.
  • This conversion correlated with repression of slow fiber-specific genes and unchanged or enhanced fast fiber-specific gene expression.

    • Conclusions:

    • hMusTRD1alpha1 acts as a repressor of slow fiber-specific genes.
    • Slow fiber genes likely share a common regulatory element targeted by MusTRD proteins.
    • hMusTRD1alpha1 plays a significant role in postnatal muscle fiber type conversion.