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The PILATUS 1M detector.

Ch Broennimann1, E F Eikenberry, B Henrich

  • 1Paul Scherrer Institute, CH-5232 Villigen, Switzerland. cristian.broennimann@psi.ch

Journal of Synchrotron Radiation
|February 24, 2006
PubMed
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The PILATUS 1M detector, a large single photon counting hybrid pixel array detector, enables advanced macromolecular crystallography. This silicon pixel detector facilitates refined electron density map determination for biological crystals.

Area of Science:

  • X-ray crystallography
  • Detector physics
  • Materials science

Background:

  • Macromolecular crystallography demands sensitive, high-resolution detectors.
  • Synchrotrons provide intense X-ray sources crucial for crystallographic studies.
  • Advancements in hybrid pixel detector technology are essential for pushing scientific boundaries.

Purpose of the Study:

  • To introduce and characterize the PILATUS 1M detector for macromolecular crystallography.
  • To evaluate the performance of a large-area, single photon counting detector in a synchrotron environment.
  • To demonstrate the feasibility of using silicon pixel detectors for refined electron density map determination.

Main Methods:

  • The PILATUS 1M detector, a modular system with over one million pixels, was designed and manufactured at PSI.

Related Experiment Videos

  • Charge collection properties of the silicon sensor were studied for single photon counting applications.
  • Data acquisition was performed in both conventional oscillation and fine-varphi-slicing modes at the Swiss Light Source.
  • Data processing involved applying corrections and merging data to obtain R-factors.

    • Main Results:

    • The PILATUS 1M detector, covering 21 cm x 24 cm, operates in single photon counting mode with a readout time of 6.7 ms.
    • Testing at the Swiss Light Source demonstrated successful data collection in various modes.
    • Processing conventional data from a thaumatin crystal yielded satisfactory merging R-factors of approximately 8.5%.

    Conclusions:

    • The PILATUS 1M detector represents a significant advancement for macromolecular crystallography.
    • This silicon pixel detector enables the determination of refined electron density maps for biological crystals.
    • The detector's performance validates its use in cutting-edge crystallographic research.