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Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits (Oryctolagus cuniculus)
Published on: July 31, 2021
[Prevention of fetomaternal rhesus-D allo-immunization. Practical aspects]
1Centre National de Référence en Hémobiologie Périnatale (CNRHP), Hôpital Saint-Antoine, 184, rue du Faubourg-Saint-Antoine, 75012 Paris.
Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction
|February 24, 2006
Summary
RhD prophylaxis prevents RhD negative mothers from developing anti-D antibodies. This involves routine antenatal and targeted prophylaxis to prevent fetal blood entering the mother's circulation.
Area of Science:
- Immunology
- Obstetrics
- Perinatal Medicine
Context:
- RhD prophylaxis is crucial for RhD-negative women carrying RhD-positive fetuses.
- It aims to prevent anti-D immunization from feto-maternal hemorrhage (FMH).
- Two main types exist: routine antenatal and targeted prophylaxis.
Purpose:
- To outline current guidelines and practices for RhD prophylaxis.
- To detail the administration, dosage, and timing of anti-D immunoglobulin.
- To discuss criteria for abstaining from prophylaxis and post-delivery procedures.
Summary:
- RhD prophylaxis involves administering anti-D immunoglobulin to RhD-negative women to prevent alloimmunization.
- Dosing strategies depend on the volume of FMH, with intravenous administration preferred.
- Routine prophylaxis is given at 28 weeks, with targeted prophylaxis for specific events; abstention is possible with confirmed RhD-negative status.
Impact:
- Ensures effective prevention of hemolytic disease of the newborn.
- Guides clinical practice for RhD-negative pregnancies.
- Highlights the importance of accurate FMH quantification and timely intervention.
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