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Nocardia keratitis: a case report.

S Matuska1, P Rama, A Cavallero

  • 1Department of Ophthalmology and Visual Sciences, University Hospital San Raffaele, Milano, Italy.

European Journal of Ophthalmology
|February 24, 2006
PubMed
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Nocardia keratitis resistant to amikacin can occur. Topical corticosteroids may trigger infection relapse, necessitating prolonged antibiotic treatment with combination therapy.

Area of Science:

  • Ophthalmology
  • Medical Microbiology

Background:

  • Nocardia keratitis is a serious ocular infection.
  • Prompt diagnosis and appropriate antimicrobial therapy are crucial for successful treatment.

Observation:

  • A case of Nocardia keratitis resistant to 2% amikacin was observed.
  • Fortified topical 5% amikacin led to a toxic-allergic reaction.
  • Recurrence of infection occurred after topical corticosteroid use.

Findings:

  • Nocardia asteroides was identified as the causative agent.
  • A combination of chloramphenicol, tetracycline, colistin, and ofloxacin proved effective.
  • Prolonged treatment (3 months) was required for resolution.

Implications:

Related Experiment Videos

  • Topical amikacin may exhibit resistance in Nocardia keratitis cases.
  • Topical corticosteroids should be used cautiously due to potential for relapse.
  • Combination antibiotic therapy is a viable treatment option for resistant Nocardia keratitis.