Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Speckles in laser Doppler perfusion imaging.

V Rajan1, B Varghese, T G van Leeuwen

  • 1Biomedical Technology Institute, Biophysical Engineering Group, University of Twente, P.O. Box 217, NL-7500AE Enschede, The Netherlands. v.rajan@tnw.utwente.nl

Optics Letters
|February 25, 2006
PubMed
Summary

Speckles quantitatively influence laser Doppler perfusion imaging by affecting signal amplitude and Doppler spectrum. Narrow beams and tissue scattering significantly impact these speckle effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comprehensive assessment of adults severely ill with TB referred after triage in Tamil Nadu, India.

Public health action·2026
Same author

Long-term functional outcomes following non-surgical management of completely displaced midshaft clavicle fractures in adolescents (12-16 years): a retrospective cohort study with 11-year follow-up.

Annals of the Royal College of Surgeons of England·2026
Same author

Role of triage audit in an ongoing differentiated TB care initiative to reduce deaths in Tamil Nadu, India.

Public health action·2025
Same author

Correction to "Mixed Substituted Porphyrins: Structural and Electrochemical Redox Properties".

Inorganic chemistry·2025
Same author

Contrast-enhanced Ultrasound Imaging Following Transperineal Laser Ablation for Lower Urinary Tract Symptoms.

Urology·2024
Same author

Role of Electronegativity on the Elemental Diversity in High-Entropy Alloys.

Journal of the American Chemical Society·2024

Area of Science:

  • Biomedical Optics
  • Laser Physics
  • Medical Imaging

Background:

  • Laser Doppler perfusion imaging (LDPI) is a technique used to measure blood flow.
  • Speckle patterns arise from the interference of coherent light scattered by particles.
  • Understanding speckle influence is crucial for accurate LDPI signal interpretation.

Purpose of the Study:

  • To quantitatively assess the influence of speckles on laser Doppler perfusion imaging.
  • To investigate how speckle effects vary with particle scattering and beam width.
  • To determine the impact of tissue type on speckle-related instrumental response.

Main Methods:

  • Experimental demonstration using particle suspensions with varying scattering properties.
  • Systematic variation of laser beam width.

Related Experiment Videos

  • Analysis of speckle influence on signal amplitude and Doppler spectrum.

    • Main Results:

    • Speckles significantly affect both signal amplitude and the Doppler spectrum in LDPI.
    • The degree of speckle influence is dependent on particle scattering levels and beam width.
    • Tissue type modulates instrumental response due to lateral light diffusion affecting speckle count.
    • Narrow beams exhibit the most pronounced speckle effects.

    Conclusions:

    • Speckle phenomena are a critical factor influencing quantitative accuracy in laser Doppler perfusion imaging.
    • Instrumental response in LDPI is modulated by tissue optical properties and beam geometry.
    • Careful consideration of speckle effects, particularly with narrow beams, is necessary for reliable perfusion measurements.