Related Experiment Videos
[Age specific reference ranges and clinical trial for complexed prostate specific antigen (cPSA)]
Riichi Haga1, Hiroji Shimomura, Yuko Ishizakaa
1Central Clinical Laboratory, Mitsui Memorial Hospital, Chiyoda-ku, Tokyo 101-8643.
Rinsho Byori. the Japanese Journal of Clinical Pathology
|February 28, 2006
Summary
This study establishes age-specific reference ranges for complexed PSA (cPSA) and total PSA in men. Findings reveal an upward trend in both markers with increasing age, crucial for accurate prostate health assessment.
Area of Science:
- Urology
- Biochemistry
- Gerontology
Context:
- Prostate cancer screening relies on prostate-specific antigen (PSA) levels.
- Establishing age-specific reference ranges is vital for accurate interpretation of PSA values.
- Previous studies have not comprehensively defined age-based cPSA reference ranges.
Purpose:
- To compare age-specific reference ranges for complexed PSA (cPSA) and total PSA.
- To establish expected result ranges for cPSA across different age groups in men.
- To investigate the relationship between age and PSA levels in a large cohort.
Summary:
- A study of 1,210 men found that both cPSA and total PSA levels increase with age.
- Defined 95th percentile upper limit values for cPSA across age groups: <40 years (1.38 ng/ml), 40-49 (1.60 ng/ml), 50-59 (2.25 ng/ml), 60-69 (2.50 ng/ml), and ≥70 (4.31 ng/ml).
- Total PSA also showed an age-related increase, with values ranging from 1.85 ng/ml to 5.69 ng/ml across the same age brackets.
Impact:
- Provides age-adjusted reference ranges for cPSA, potentially improving diagnostic accuracy in prostate health.
- Highlights the importance of age-specific interpretation of PSA biomarkers.
- Contributes to a better understanding of age-related changes in prostate tumor markers.