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The human polyomaviruses.

S Eash1, K Manley, M Gasparovic

  • 1Graduate Program in Pathobiology, Brown University, Providence, Rhode Island, 02912, USA.

Cellular and Molecular Life Sciences : CMLS
|February 28, 2006
PubMed
Summary
This summary is machine-generated.

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BK virus (BKV) and JC virus (JCV) infect humans, remaining latent until immunosuppression reactivates them. Reactivation causes serious conditions like nephropathy and progressive multifocal leukoencephalopathy.

Area of Science:

  • Virology
  • Immunology
  • Infectious Diseases

Background:

  • BK virus (BKV) and JC virus (JCV) are human polyomaviruses widely prevalent globally.
  • Primary infection occurs in childhood, typically asymptomatic in immunocompetent individuals.
  • Reactivation under severe immunosuppression can lead to severe diseases.

Purpose of the Study:

  • To examine the biological characteristics and lifecycle of BKV and JCV.
  • To review the clinical manifestations of polyomavirus-induced disorders.
  • To discuss the potential role of BKV and JCV in human cancers.

Main Methods:

  • Literature review of BKV and JCV characteristics.
  • Analysis of viral lifecycle stages: receptor interaction, entry, trafficking, transcription, replication, and assembly.

Related Experiment Videos

  • Overview of clinical presentations and oncogenic potential.

    • Main Results:

    • BKV and JCV share common lifecycle pathways but cause distinct diseases.
    • Polyomavirus-induced nephropathy (BKV) and progressive multifocal leukoencephalopathy (JCV) are linked to immunosuppression.
    • Evidence suggests a potential role for these viruses in certain human cancers.

    Conclusions:

    • Understanding BKV and JCV biology is crucial for managing associated diseases.
    • Further research is needed to elucidate their oncogenic mechanisms.
    • Clinical vigilance for polyomavirus reactivation in immunocompromised patients is essential.