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Alexander's disease: a case report with brain biopsy, ultrasound, CT scan and MRI findings
A O Arend1, P M Leary, G S Rutherfoord
1Institute of Child Health, University of Cape Town, South Africa.
Clinical Neuropathology
|May 1, 1991
Abstract:
Alexander's disease is reported in a 6-month-old infant. The clinical course was characterized by hydrocephalus, irritability and psychomotor retardation, with subsequent seizures and spasticity. Findings on ultrasound examination, computerized tomography, magnetic resonance imaging and brain biopsy are presented. The glial nature of the Rosenthal fibers was confirmed by immuno-gold staining. Clinical classification and differential diagnosis are discussed.