Related Experiment Video

Updated: Aug 11, 2026

Repeated Transcranial Magnetic Stimulation Combined with Action Observation Training in Children with Spastic Cerebral Palsy
07:20

Repeated Transcranial Magnetic Stimulation Combined with Action Observation Training in Children with Spastic Cerebral Palsy

Published on: August 9, 2024

Surgical treatment of two patients with infantile spasms in early infancy

Hoon-Chul Kang1, Da Eun Jung, Kae Min Kim

  • 1Department of Pediatrics, Epilepsy Center, Sang-gye Paik Hospital, Inje University College of Medicine, Sang-gye 7 Dong 761-1, No-won Gu, Seoul 139-707, South Korea.

Brain & Development
|March 1, 2006
PubMed

Insights

Early epilepsy surgery in infants under six months can prevent developmental decline. Surgical interventions for infantile spasms, like lesionectomy and disconnection, led to positive outcomes, though transfusion risks were noted.

Area of Science:

  • Pediatric Neurology
  • Neurosurgery
  • Developmental Neuroscience

Background:

  • Infantile spasms are a severe epilepsy syndrome in infants.
  • Early intervention is crucial to prevent developmental deficits.
  • Surgical options for intractable infantile spasms are being explored.

Observation:

  • Two infants younger than six months with infantile spasms and cortical dysplasia underwent epilepsy surgery.
  • One patient had a lesionectomy; the other had a disconnection surgery.
  • Both patients achieved favorable outcomes (Engel classification I) with developmental catch-up.

Findings:

  • Early surgical treatment for catastrophic epilepsy in infancy is feasible.
  • Surgical interventions can lead to significant developmental progress.
  • Potential risks, such as high-volume transfusion in extensive procedures, require careful management.

Implications:

  • Early epilepsy surgery may be a viable option for infants with catastrophic epilepsy.
  • Minimizing functional deficits and developmental deterioration is possible with timely surgical intervention.
  • Further research is needed to optimize surgical strategies and manage risks in this population.

More Related Videos

Frontal Disconnection for Treating Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE) in the Frontal Lobe06:04

Frontal Disconnection for Treating Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE) in the Frontal Lobe

Published on: August 16, 2024

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy09:57

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy

Published on: September 20, 2024

Related Concept Videos

Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx as...
Classification of Skeletal Muscle Relaxants01:28

Classification of Skeletal Muscle Relaxants

Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...