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[Can virus cause oral cancers?].

A Heyden1, S P Lyngstadaas, P S Thrane

  • 1Institutt for Patologi, Universitetet i Oslo.

Den Norske Tannlaegeforenings Tidende
|March 1, 1991
PubMed
Summary

Tumour viruses like human papilloma virus (HPV) can cause cancer by integrating into cellular DNA. This integration may activate oncogenes, leading to malignant transformation and oral squamous cell carcinoma.

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Area of Science:

  • Oncology
  • Virology
  • Molecular Biology

Context:

  • Tumour viruses are implicated in approximately 20% of human cancers.
  • Human papilloma virus (HPV), a DNA virus, is specifically linked to oral carcinomas.
  • The precise mechanisms by which viruses contribute to cancer development remain largely unknown.

Purpose:

  • To explore the role of tumour viruses, particularly HPV, in the development of oral cancers.
  • To investigate the mechanisms of viral DNA integration into host cellular DNA and its consequences.
  • To examine the interplay between viral integration, cellular oncogenes, and tumour suppressor genes in oral carcinogenesis.

Summary:

  • Viral DNA integration into host cellular DNA is a critical step for malignant transformation.
  • HPV DNA integration near cellular oncogenes can lead to their activation, promoting cancer.
  • The study also considers other cellular factors contributing to oral squamous cell carcinoma.

Impact:

  • This research enhances understanding of viral oncogenesis, specifically in oral cancer.
  • Identifies potential molecular targets for cancer prevention and therapy.
  • Provides insights into the complex interactions between viral and cellular genetic material in cancer development.

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