Related Experiment Video
Updated: Aug 1, 2026

Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice
Published on: July 25, 2014
Bacteriophages and transplantation tolerance
A Górski1, M Kniotek, A Perkowska-Ptasińska
1Transplantation Institute, Warsaw Medical University, 02-006 Warsaw, Poland.
Abstract:
Our recent findings suggest that bacteriophages (phages) may not only eliminate bacteria, but also modulate immune functions. In this communication, we demonstrate that phages may strongly inhibit human T-cell activation and proliferation as well as activation of the nuclear transcription factor NF-kappaB in response to a viral pathogen. Phage administration in vivo can diminish cellular infiltration of allogeneic skin allografts. Thus, phage treatment should be considered in antibiotic-resistant posttransplantation infections. Furthermore, phages could find a broader application in clinical transplantation.
Related Concept Videos
Lytic Cycle of Bacteriophages
Cell-mediated Immune Responses
Tissue Transplantation
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Transduction
Viral Replication: Lysogenic Cycle
Bacteriophages of the Human Virome

