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Updated: Aug 11, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
New therapies for systemic lupus erythematosus: cellular targets
R John Looney1, Jennifer Anolik, Iñaki Sanz
1Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY14420, USA. john_looney@urmc.rochester.edu
Abstract:
Antilymphocyte antibodies have been widely used in oncology and transplantation and are now being tested in autoimmune diseases. For systemic lupus erythematosus, anti-B-cell antibodies are furthest along in development. This article discusses the B-cell abnormalities found in systemic lupus erythematosus and the clinical and immunologic effects of anti-B-cell therapies.
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