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Probucol and atorvastatin decrease urinary 8-hydroxy-2'-deoxyguanosine in patients with diabetes and
Kei Endo1, Yoh Miyashita, Hidehisa Sasaki
1Center of Diabetes, Endocrinology and Metabolism, Sakura Hospital, Toho University, Chiba, Japan.
Journal of Atherosclerosis and Thrombosis
|March 1, 2006
Summary
Both probucol and atorvastatin reduce oxidative stress in diabetic patients with high cholesterol. Probucol may be more effective for those with severe oxidative stress.
Area of Science:
- Cardiology
- Endocrinology
- Biochemistry
Background:
- Diabetic patients with hypercholesterolemia often experience elevated oxidative stress.
- Oxidative stress contributes to diabetic complications.
- Statins and probucol are used to manage hypercholesterolemia, but their effects on oxidative stress in diabetics require clarification.
Purpose of the Study:
- To compare the effects of probucol and atorvastatin on urinary 8-hydroxy-2'deoxyguanosine (8-OHdG) levels, a marker of oxidative stress, in patients with type 2 diabetes and hypercholesterolemia.
Main Methods:
- A randomized, open study involving 36 patients with type 2 diabetes and hypercholesterolemia.
- Patients were assigned to receive either probucol (500 mg/day) or atorvastatin (10 mg/day) for three months.
- Urinary 8-OHdG levels were measured before and after treatment.
Main Results:
- Both probucol and atorvastatin significantly reduced total and LDL cholesterol.
- Both treatments significantly decreased urinary 8-OHdG levels after three months.
- Probucol showed a potentially greater reduction in 8-OHdG in patients with initially high oxidative stress levels.
Conclusions:
- Both probucol and atorvastatin effectively reduce systemic oxidative stress in diabetic patients with hypercholesterolemia.
- Probucol may offer a more significant benefit in managing oxidative stress for patients with severe oxidative stress.