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The effect of ephedrine and phenylephrine on BIS values during propofol anaesthesia
D Takizawa1, E Takizawa, S Miyoshi
1Gunma University, Graduate School of Medicine, Department of Anesthesiology, Maebashi, Japan. d-takiza@bf6.so-net.ne.jp
Background:
The purpose of this study was to evaluate the effect of ephedrine and phenylephrine on propofol concentrations and bispectral index during propofol anesthesia.
Methods:
General anaesthesia was induced with propofol and was maintained with propofol (4 mg kg-1 h-1) and fentanyl. Vecuronium was used to facilitate the artificial ventilation of the lungs. Patients with systolic blood pressure > 90 mmHg were defined as the control group (n = 16). Patients who had to be treated for larger decreases in arterial blood pressure (systolic blood pressure 60, whereas no patient in the control or phenylephrine groups had bispectral index >60. There were no significant differences in propofol concentrations or cardiac output relative to baseline at 3 or 10 min after the administration of ephedrine or phenylephrine.
Conclusions:
Ephedrine increases bispectral index values without decreasing propofol concentrations during general anesthesia.
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