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[Adrenal androgen and bone metabolism].
Kiminobu Goto1, Toshihiko Yanase, Ryoichi Takayanagi
1Kasamatsu-kai Medical Corporation Ariyoshi Hospital, Internal Medicine and the Elderly Care.
Clinical Calcium
|March 2, 2006
Summary
Dehydroepiandrosterone-sulfate (DHEA-S) is abundant but has weak activity. However, dehydroepiandrosterone (DHEA) may increase bone mineral density in older adults, warranting further large-scale trials.
Area of Science:
- Endocrinology
- Gerontology
- Bone Metabolism
Background:
- Dehydroepiandrosterone-sulfate (DHEA-S) is the most prevalent human steroid.
- Despite its abundance, DHEA-S exhibits limited documented biological activity.
- Emerging evidence suggests a potential role for dehydroepiandrosterone (DHEA) in bone health.
Purpose of the Study:
- To investigate the potential of dehydroepiandrosterone (DHEA) in improving bone mineral density.
- To assess the clinical relevance of DHEA supplementation in the elderly population.
Main Methods:
- Review of recent basic and clinical observations.
- Identification of the need for large-scale, double-blinded clinical trials.
Main Results:
- Preliminary data suggest DHEA may positively influence bone mineral density.
- The elderly population shows potential benefit from DHEA regarding bone health.
Conclusions:
- Dehydroepiandrosterone (DHEA) shows promise for enhancing bone mineral density in the elderly.
- Rigorous, large-scale, double-blinded clinical trials are essential to confirm these findings and establish efficacy.