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Molecular evolution of adrenoceptors and dopamine receptors: implications for the binding of catecholamines

Henri Xhaard1, Ville-Veikko Rantanen, Tommi Nyrönen

  • 1Department of Biochemistry and Pharmacy, Abo Akademi University, FI-20520 Turku, Finland.

Journal of Medicinal Chemistry
|March 3, 2006
PubMed

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Adrenergic receptors, or adrenoceptors, respond to the autonomic neurotransmitter noradrenaline and other endogenous catecholamine agonists. They are classified into two main families, α and β, based on their pharmacological response and are further subdivided depending on their location, elicited response, and affinity to specific agonists or antagonists.
α-Adrenoceptors
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Adrenergic agonists' structure-activity relationship (SAR) determines their selectivity and efficacy. These agonists comprise a phenylethylamine moiety with an aromatic ring and an ethylamine side chain.
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