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Updated: Aug 11, 2026

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
19:57

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings

Published on: March 30, 2014

Achieving adherence to antiretroviral medications for pediatric HIV disease using an empirically supported treatment:

Phillippe B Cunningham1, Sylvie Naar-King, Deborah A Ellis

  • 1Family Services Research Center, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA. cunninpb@musc.edu

Journal of Developmental and Behavioral Pediatrics : JDBP
|March 3, 2006
PubMed

Insights

Adherence to antiretroviral therapy in children with HIV is complex. Multisystemic therapy (MST) offers a promising, intensive home-based approach for improving medication adherence in adolescents.

Area of Science:

  • Pediatric infectious diseases
  • Adolescent health
  • Mental health services

Background:

  • Adherence to antiretroviral therapy (ART) in children with human immunodeficiency virus (HIV) is crucial for treatment success.
  • Psychosocial factors related to the child, caregiver, medical team, and medications significantly impact ART adherence.
  • Flexible and comprehensive treatment strategies are needed to address these multifaceted challenges.

Observation:

  • Multisystemic therapy (MST) is an evidence-based, intensive, home-based intervention.
  • MST has demonstrated effectiveness in managing other chronic pediatric conditions.
  • This case report details the application of MST in an adolescent with perinatally acquired HIV and poor ART adherence.

Findings:

  • MST addresses the complex psychosocial determinants of ART adherence in pediatric HIV.
  • The intensive, home-based nature of MST facilitates engagement and adherence support.
  • Case study indicates potential for MST to improve ART adherence in non-adherent adolescents.

Implications:

  • MST may represent a viable therapeutic option for improving ART adherence in pediatric and adolescent HIV populations.
  • Integrating MST into HIV care could enhance long-term health outcomes for affected youth.
  • Further research is warranted to evaluate MST's efficacy and scalability in pediatric HIV care.

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