[Prophylaxis of bipolar disorder]
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Updated: Aug 11, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Andrea Sterr1, Benedikt Amann, Heinz Grunze
1Psychiatrische Universitätsklinik der LMU München.
Abstract:
Until recently, the psychopharmacological treatment alternatives for bipolar maintenance treatment were limited to lithium, which seems of special usefulness in a classical manifestation of the illness with mood-stabilising and anti-suicidal properties. With atypical features like psychotic symptoms or rapid cycling, lithium seems to be less useful. This led to further research into alternative options as carbamazepine, valproate or lamotrigine as well as atypical neuroleptics, thyroid hormones or innovative substances like omega fatty acids. This article summarises the current state of knowledge on treatment options for maintenance therapy.
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