Related Experiment Video
Updated: Jul 31, 2026

07:25
Ultrasonographic Evaluation of Salivary Glands for Sjogren's Syndrome: Diagnostic and Monitoring Insights
Published on: October 13, 2023
[MALT-lymphomas in Sjogren's disease]
Terapevticheskii Arkhiv
|March 4, 2006
Summary
Early diagnosis of extranodal lymphoma in Sjögren's disease (SD) is crucial. Persistent salivary gland enlargement in SD patients warrants biopsy for early detection of MALT-lymphoma.
Area of Science:
- Rheumatology
- Oncology
- Pathology
Context:
- Sjögren's disease (SD) is an autoimmune disorder primarily affecting exocrine glands.
- Patients with SD have an increased risk of developing lymphoproliferative disorders, particularly extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT-lymphoma).
- Early diagnosis of MALT-lymphoma in SD is challenging but essential for timely intervention and improved prognosis.
Purpose:
- To develop an algorithm for the early diagnosis of extranodal MALT-lymphoma in patients with Sjögren's disease.
- To identify key clinical and morphological features indicative of MALT-lymphoma development in SD patients.
- To establish diagnostic criteria for MALT-lymphoma in the salivary and lacrimal glands of SD patients.
Summary:
- A study of 457 Sjögren's disease patients identified 38 with lymphoproliferative diseases, including 15 with MALT-lymphoma.
- MALT-lymphoma most frequently affected salivary glands (parotid, submandibular, minor) and lacrimal glands, predominantly at stages I-II.
- Clinical indicators for MALT-lymphoma in SD include persistent salivary gland enlargement (>12 months), monoclonal immunoglobulins in serum, and light chains in urine.
Impact:
- This research provides a framework for the early detection of MALT-lymphoma in Sjögren's disease patients.
- Biopsy of enlarged parotid glands in SD patients is recommended for early diagnosis of malignant lymphoproliferation.
- Improved diagnostic strategies can lead to earlier treatment initiation and potentially better outcomes for SD patients with MALT-lymphoma.
More Related Videos
Related Concept Videos
Lymphoid Cells and Tissues
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Primary Lymphoid Organs
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Secondary Lymphoid Organs
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
T Cell Types and Functions
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Autoimmune Disorders
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Concept and Mechanism of Autoimmune Diseases
The immune system...

