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Related Experiment Video

Updated: May 12, 2025

Performing and Processing FNA of Anterior Fat Pad for Amyloid

Performing and Processing FNA of Anterior Fat Pad for Amyloid

Published on: October 30, 2010

[Localized AL amyloidosis].

N A Kashchavtseva¹, I G Rekhtina¹, A M Kovrigina^1,2

¹National Medical Research Center for Hematology.

Terapevticheskii Arkhiv

|May 6, 2025

Summary

This summary is machine-generated.

Localized light chain (AL) amyloidosis, a rare condition, can manifest as amyloidomas in various tissues. Targeted therapy showed stabilization in three patients, but its standard use requires further research.

Keywords:

amyloidoma localized AL amyloidosis

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Last Updated: May 12, 2025

Performing and Processing FNA of Anterior Fat Pad for Amyloid

Performing and Processing FNA of Anterior Fat Pad for Amyloid

Published on: October 30, 2010

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

Published on: October 20, 2017

Rapid Generation of Amyloid from Native Proteins In vitro

Rapid Generation of Amyloid from Native Proteins In vitro

Published on: December 5, 2013

Area of Science:

Oncology
Pathology
Immunology

Background:

Localized light chain (AL) amyloidosis (amyloidoma) is a rare neoplastic disorder.
Its pathogenesis and therapeutic strategies remain poorly understood.
This study focuses on localized AL amyloidosis affecting the respiratory tract, eyes, and facial soft tissues.

Purpose of the Study:

To present clinical observations of localized AL amyloidosis.
To investigate the cellular origin and amyloid typing in these rare cases.
To evaluate the efficacy of systemic combination therapy with targeted drugs.

Main Methods:

Chromogenic in situ hybridization (CISH) with immunoglobulin light chain probes to identify the cell substrate.
FITC-labeled antibodies for kappa and lambda light chain detection in amyloid typing.
Systemic combination therapy with targeted drugs followed by one-year follow-up.

Main Results:

Three clinical cases of localized AL amyloidosis with amyloid masses containing monotypic plasma cells were observed.
Amyloid typing confirmed the light chain origin of the deposits.
All patients achieved process stabilization within one year of follow-up with targeted therapy.

Conclusions:

Localized AL amyloidosis presents as amyloidomas with embedded monotypic plasma cells.
Systemic combination therapy with targeted drugs demonstrated stabilization in observed cases.
The role of clone-reducing therapy in localized AL amyloidosis warrants further investigation and confirmation.