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Duration of effects of aspirin on platelet function in healthy volunteers: an analysis using the PFA-100
Christoph J Konrad1, Guido K Schuepfer, Helmut Gerber
1Clinical Pain Research and Pain Clinics, Institute of Anesthesiology and Intensive Care Medicine, University Clinics Mannheim, Ruprecht Karls-University of Heidelberg, 68167 Mannheim, Germany. christoph.konrad@anaes.ma.uni-heidelberg.de
Study Objective:
The aim of the study was to determine the duration and effects of aspirin on platelet function.
Study Design:
Prospective investigation.
Setting:
Blood samples from volunteers. PATIENTS AND MONITORING: Ten healthy male volunteers took part in this investigation. After having measured baseline hemostatic parameters, 2000-mg aspirin was taken orally. Subsequently, the hemostatic profile had been compiled daily for a duration of 4 days after ingestion.
Measurements And Main Results:
Platelet function was analyzed (1) after 3 hours and (2) daily for 4 days by the platelet function analyzer (PFA-100, Dade Co, Miami, Fla), which represents a sensitive investigation method for measuring platelet function and dysfunction. Routine hemostatic parameters were investigated. Three hours after ingestion of aspirin, abnormal PFA-100 values could be detected. Further detectable elevated values were found during the following 3 days.
Conclusion:
Effects of single-dose aspirin 2000 mg on platelet function were detected after 3 hours and had been lasting for the following 3 days. This result shows that PFA-100 may help by evaluating hemostasis during the preoperative period.
