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Updated: Aug 11, 2026

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia
Published on: November 10, 2023
Importance of the bone marrow microenvironment in inducing the angiogenic response in multiple myeloma
1Department of Human Anatomy and Histology, University of Bari Medical School, Italy. ribatti@anatomia.uniba.it
Abstract:
Tumor microenvironment is essential for tumor cell proliferation, angiogenesis, invasion and metastasis through its provision of survival signals, secretion of growth and pro-angiogenic factors, and direct adhesion molecule interactions. This review examines its importance in the induction of an angiogenic response in multiple myeloma (MM). The encouraging results of preclinical and clinical trials in which MM has been treated by targeting the tumor microenvironment are also discussed.
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