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Peripheral nerve lesions in hemophilia.
S G Katz1, I W Nelson, R M Atkins
1Department of Orthopaedic Surgery, Nuffield Orthopaedic Centre, Headington, Oxford, England.
The Journal of Bone and Joint Surgery. American Volume
|August 1, 1991
Summary
Peripheral nerve lesions are common in hemophilia patients. Those with factor VIII antibodies experienced significantly poorer motor and sensory recovery outcomes.
Area of Science:
- Orthopedics
- Hematology
- Neurology
Background:
- Peripheral nerve lesions are a known complication in patients with hemophilia.
- The Nuffield Orthopaedic Centre managed a significant number of hemophilia admissions between 1962 and 1986.
Purpose of the Study:
- To investigate the incidence and outcomes of peripheral nerve lesions in patients with hemophilia.
- To identify factors influencing recovery from these nerve injuries.
Main Methods:
- Retrospective review of 1351 hemophilia admissions between 1962 and 1986.
- Identification and analysis of 88 peripheral nerve lesions in 54 patients.
- Assessment of motor and sensory recovery in 39 patients with adequate follow-up (mean 8.4 years).
Main Results:
- Eighty-one admissions were for peripheral nerve lesions.
- The femoral nerve was the most frequently affected.
- Full motor and sensory recovery occurred in 49% of lesions; 34% had sensory deficits, and 16% had both motor and sensory deficits.
- Patients with factor VIII antibodies showed significantly worse recovery and longer recovery times.
Conclusions:
- Peripheral nerve lesions represent a notable complication in hemophilia care.
- The presence of factor VIII antibodies is a significant negative prognostic factor for nerve recovery in hemophilia patients.