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Updated: Aug 11, 2026

An In Vitro Hemodynamic Loop Model to Investigate the Hemocytocompatibility and Host Cell Activation of Vascular Medical Devices
08:44

An In Vitro Hemodynamic Loop Model to Investigate the Hemocytocompatibility and Host Cell Activation of Vascular Medical Devices

Published on: August 21, 2020

Interaction of hemoglobin vesicles, a cellular-type artificial oxygen carrier, with human plasma: effects on

Hideki Abe1, Mitsuhiro Fujihara, Hiroshi Azuma

  • 1Hokkaido Red Cross Blood Center, Japanese Red Cross, Yamanote 2-2, Nishi-ku, Sapporo 063-0002, Japan. abeh@hokkaido.bc.jrc.or.jp

Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
|March 8, 2006
PubMed

Hemoglobin vesicles (HbVs), cellular-type artificial oxygen carriers containing human hemoglobin, were assessed for their biocompatibility by mixing with human plasma in vitro. Among three kinds of HbVs (PEG-DPEA-HbV, PEG-DPPG-HbV and DPPG-HbV), PEG-DPEA-HbV did not affect the extrinsic or intrinsic coagulation activities of the plasma, while PEG-DPPG-HbV and DPPG-HbV tended to shorten the intrinsic coagulation time. The kallikrein-kinin cascade of the plasma was slightly activated by PEG-DPPG-HbV and DPPG-HbV, but not by PEG-DPEA-HbV. The complement consumption of the plasma was observed by incubation with DPPG-HbV, but not with PEG-DPEA-HbV or PEG-DPPG-HbV. These results indicate that PEG-DPEA-HbV has a higher biocompatibility with human plasma.

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