Related Experiment Video
Updated: Aug 11, 2026

Dynamic Electrochemical Measurement of Chloride Ions
Published on: February 5, 2016
Recommendation for measuring and reporting chloride by ISEs in undiluted serum, plasma or blood
Mohammed C Ben Rayana1, Robert W Burnett, Arthur K Covington
1Laboratory of Clinical Chemistry, National Institute of Nutrition, Bab Saadoun, Tunis, Tunisia.
Abstract:
The proposed recommendation for measuring and reporting chloride in undiluted plasma or blood by ion-selective electrodes (ISEs) will provide results that are identical to chloride concentrations measured by coulometry for standardized normal plasma or blood samples. It is applicable to all current ISEs dedicated to chloride measurement in undiluted samples that meet the requirements. However, in samples with reduced water concentration, results by coulometry are lower than by ion-selective electrode due to volume displacement. The quantity measured by this standardized ISE procedure is called the ionized chloride concentration. It may be clinically more relevant than the chloride concentration as determined by coulometry, photometry or by ISE after dilution of the sample.
More Related Videos
05:42Measurement of Ion Concentration in the Unstirred Boundary Layer with Open Patch-Clamp Pipette: Implications in Control of Ion Channels by Fluid Flow
Published on: January 7, 2019
13:30Use of the Ramsay Assay to Measure Fluid Secretion and Ion Flux Rates in the Drosophila melanogaster Malpighian Tubule
Published on: November 25, 2015
Related Concept Videos
Precipitation Titration Curve: Analysis
Transport Number
Ion-Exchange Chromatography
Precipitation Titration: Endpoint Detection Methods
In the Volhard method, a standard excess of AgNO3 is first added to the...
Precipitation of Ions
The equation that describes the equilibrium between solid calcium carbonate and its solvated ions is: