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IL-9 expression contributes to the cellular composition in Hodgkin lymphoma
Ingrid Glimelius1, Annika Edström, Rose-Marie Amini
1Department of Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala, Sweden. ingrid.glimelius@onkologi.uu.se
European Journal of Haematology
|March 8, 2006
Summary
Interleukin-9 (IL-9) expression in Hodgkin lymphoma (HL) correlates with increased eosinophils and mast cells. This suggests IL-9 plays a role in the inflammatory infiltrate within HL tumors.
Area of Science:
- Oncology
- Immunology
- Pathology
Background:
- Hodgkin lymphoma (HL) prognosis is negatively impacted by mast cells and eosinophils.
- Interleukin-9 (IL-9) is a cytokine known to influence mast cells and eosinophils.
Purpose of the Study:
- To investigate the correlation between IL-9 expression and the presence of inflammatory cells in HL tumors.
- To explore the role of IL-9 in the tumor microenvironment of Hodgkin lymphoma.
Main Methods:
- Immunostaining for IL-9 and IL-9 receptor (IL-9R) was performed on 131 HL biopsies.
- Data on mast cells, eosinophils, and clinical/survival information were analyzed.
Main Results:
- IL-9 was expressed in 53% of HL cases; IL-9R in 19%.
- IL-9 positive tumors showed significantly higher counts of eosinophils (P=0.002) and mast cells (P=0.02).
- IL-9 positivity was associated with nodular sclerosis histology, elevated white-blood-cell count, and higher erythrocyte sedimentation rate.
Conclusions:
- IL-9 expression is linked to specific HL histology, clinical features, and inflammatory cell infiltration.
- IL-9 is implicated as a significant component of the cytokine network and inflammatory infiltrate in Hodgkin lymphoma.
