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Immunoadjuvant chaperone, GRP170, induces 'danger signals' upon interaction with dendritic cells

Masoud H Manjili1, Jun-Eui Park, John G Facciponte

  • 1Department of Microbiology and Immunology, Virginia Commonwealth University, Massey Cancer Centre, Richmond, Virginia 23298, USA. mmanjili@vcu.edu

Immunology and Cell Biology
|March 8, 2006
PubMed
Summary

Glucose-regulated protein 170 (GRP170) acts as a danger signal, interacting with dendritic cells (DCs) to initiate antitumour immune responses. This occurs independently of endotoxin contamination, highlighting GRP170

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