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High-throughput screening, metabolomics and drug discovery
George G Harrigan1, Libbey A Yates
1Monsanto Co, 800 North Lindbergh Boulevard, Creve Coeur, MO 63167, USA. george.g.harrigan@monsanto.com
Idrugs : the Investigational Drugs Journal
|March 9, 2006
Summary
Metabolomics can help the pharmaceutical industry by enabling early drug discovery. This approach can reduce drug development costs and attrition rates.
Area of Science:
- Metabolomics
- Pharmacology
- Drug Discovery
Background:
- The pharmaceutical industry faces significant challenges.
- Current metabolomics applications include toxicological profiling and biomarker studies.
Purpose of the Study:
- To explore the potential of metabolomics in early drug discovery.
- To propose integrating metabolomics into early drug discovery paradigms.
Main Methods:
- Quantitative assessment of pharmacologically induced changes.
- Phenotype-level analysis of biological systems.
Main Results:
- Metabolomics can quantitatively assess drug-induced biological changes.
- Early adoption of metabolomics offers significant value.
Conclusions:
- Integrating metabolomics into early drug discovery can reduce attrition rates.
- This approach can lead to decreased costs in drug development.