Pharmacological-induced haptic changes and the accommodative performance in patients with the AT-45 accommodative IOL

Area of Science:

• Ophthalmology
• Biomedical Engineering
• Optics

Background:

• The AT-45 intraocular lens (IOL) is designed to provide accommodation.
• Understanding the in vivo mechanical performance of IOLs is crucial for visual function.

Purpose of the Study:

• To investigate the accommodative performance of the AT-45 IOL.
• To measure haptic changes, axial shift, and accommodation amplitude using 3D ultrasound biomicroscopy.

Main Methods:

• Three-dimensional ultrasound biomicroscopy was used to visualize the AT-45 IOL in four patients one month post-surgery.
• Pharmacologically induced accommodation was employed to assess haptic changes and axial shift.
• Accommodation amplitude was measured using a Hartinger coincidence refractometer.

Main Results:

• A mean change in haptic angulation of 3.3 degrees and a mean forward shift of 0.13 mm were observed.
• The mean accommodative amplitude achieved was 0.44 diopters.
• Minimal angulation and axial movements were recorded under pharmacologically induced accommodation.

Conclusions:

• The AT-45 IOL exhibits minimal mechanical changes during accommodation.
• The observed accommodative amplitude is likely insufficient for effective near work.
• Further research may be needed to optimize IOL design for improved accommodative function.