[Pharmakinetics of carboplatin in cancer patients]

Pharmakinetics of carboplatin was studied in 6 cancer patients who received carboplatin (300 mg/m2) by 30 minute intravenous infusion. Platinum plasma concentration was measured by reverse high performance liquid chromatography. The results showed that total platinum plasma clearance was biphasic in all patients with a short initial phase half-life of 1.27 hrs and a long second phase half-life of 6.92 hrs. The distribution volume of the drug was 57.78 L/m2 and area under the total platinum concentration curves was 84.71 mg/L.hr.