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Updated: Aug 10, 2026
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Published on: May 2, 2025
Liver metastases 9 years after removal of a malignant insulinoma which was initially considered benign
Abel Gonzalez-Gonzalez1, Jose María Recio-Cordova
1Department of Endocrinology and Nutrition, University Hospital Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Canary Islands, Spain. abelypaloma@tiscali.es
Context:
Insulinomas may be regarded as potentially malignant. A long follow-up period is needed to detect any possible recurrence, even if the initial diagnosis was of a benign insulinoma.
Case Report:
We present the case of a 76-year-old woman with liver metastases due to a malignant insulinoma, which had been diagnosed as benign after its complete removal 9 years earlier.
Conclusions:
This case shows the difficulty of distinguishing between benign and malignant insulinomas when there is no initial evidence of metastases. This fact poses the need to conduct a long follow-up period in order to detect any possible recurrence even if the initial diagnosis was one of a benign insulinoma.
