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Updated: Aug 10, 2026

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure
Published on: June 5, 2020
Genotoxicity and transmission electron microscopy studies of molybdocene dichloride
Kate S Campbell1, Amalanie J Foster, Carolyn T Dillon
1School of Chemistry, The University of Sydney, NSW 2006, Australia.
Abstract:
The cytotoxic effects of molybdocene dichloride (Cp(2)MoCl(2)) were investigated in V79 Chinese hamster lung cells using the micronucleus assay. Cp(2)MoCl(2) produced significant genotoxic damage whereby 0.2micronuclei/1000 binucleated cells were induced per muM of Cp(2)MoCl(2). Transmission electron microscopic analysis of thin-sectioned cells treated with Cp(2)MoCl(2) (300microM) showed distinct morphological alterations of the nuclei, condensation of chromatin, and a high incidence of polynucleated cells. Implications for the mechanism of antitumor action of molybdocene dichloride are discussed.
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