Related Experiment Video
Updated: Aug 10, 2026
Assessing Primary Motor Cortex Excitability and Excitability Modulation by Pairing Transcranial Magnetic Stimulation with Electromyography
Published on: October 7, 2025
Motor and visual cortical excitability in migraineurs patients with or without aura: transcranial magnetic
Eman M Khedr1, Mohamed A Ahmed, Khaled A Mohamed
1Neuropsychiatry Department, Assiut University Hospital, Assiut, Egypt. Emankhedr99@yahoo.com
Background And Purpose Of Study:
Controversy surrounds measures of visual and motor cortical excitability in migraineurs: some authors report that interictal excitability is increased, others decreased. The aim of this work was to provide further evidence about motor and visual cortical excitability in migraineurs between attacks.
Patients And Methods:
Twenty-eight migraineurs patients, 18 with aura and 10 patients without aura and 20 healthy right-handed, age and sex matched volunteers were included in the study. Each subject underwent transcranial magnetic stimulation and was submitted to the following: determination of resting motor threshold (rMT), silent period (SP), MEP input-output curves, phosphene threshold (PT).
Results:
Patients had lower rMT, shorter SP, and increased MEP recruitment compared with control group. There was an increased prevalence of phosphene (85%) as well as lower PT (63% of the stimulator output) in migraineurs compared with control group (75%, and 72%, respectively). There was a significant negative correlation between duration of attacks and PT (P = 0.02). No significant differences between patients with aura and without aura in different parameters of cortical excitability.
Conclusion:
Our findings confirm that the motor and visual cortexes are hyperexcitable and this appears partly to be consequent upon a failure of inhibitory circuits.
