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Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
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Published on: October 10, 2025

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A Roadmap to Transform Lung Cancer Outcomes: Priorities in Biology, Therapeutic Innovation, Early Detection,

Monte M Winslow1,2, Mohamed A Ahmed3, Christine D Berg4

  • 1Department of Genetics, Stanford University School of Medicine, Stanford, California.

Cancer Discovery
|April 19, 2026
PubMed

Insights

Lung cancer research priorities include prevention, early detection, novel treatments, and addressing disparities. Future efforts focus on precision medicine and international collaboration to improve patient outcomes.

Area of Science:

  • Oncology
  • Translational Medicine
  • Cancer Research

Background:

  • Lung cancer remains a leading cause of cancer mortality despite advances in targeted therapies, immunotherapy, and early detection.
  • Significant knowledge gaps persist, necessitating a focused research agenda to improve patient survival and outcomes.

Purpose of the Study:

  • To identify critical knowledge gaps in lung cancer research.
  • To delineate future research priorities aligned with the AACR Lung Cancer Task Force mission.
  • To propose strategies for accelerating progress in lung cancer treatment and patient care.

Main Methods:

  • Literature review and expert consensus to identify research gaps.
  • Analysis of current lung cancer research landscape.
  • Synthesis of recommendations for future research directions.

Main Results:

  • Key research priorities include enhancing prevention and early detection strategies.
  • Development of novel therapeutic approaches and improved patient stratification are crucial.
  • Addressing health disparities and focusing on understudied lung cancer subtypes are essential.

Conclusions:

  • Advancing precision medicine through international collaboration, centralized databases, innovative clinical trial designs, and AI-driven analytics is vital.
  • Elucidating drug resistance mechanisms will further enhance treatment efficacy.
  • These concerted efforts hold the promise of significantly improving lung cancer patient outcomes.

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