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Urodilatin excretion and its correlation with sodium excretion in healthy full-term newborn infants
Rosa Manganaro1, Carmelo Mamì, Alba Mancuso
1Department of Paediatric and Surgery Science, Division of Neonatology, University of Messina, 98100 Messina, Italy.
Background:
Urodilatin (URO) is a member of the natriuretic family, cleaved by the kidney, which acts as a paracrine hormone in the regulation of natriuresis and diuresis. In newborn infants the excretion of urodilatin and its biological effects have not been explored.
Methods:
We measured urinary URO excretion, by direct RIA (radioimmunoassay), as well as its correlation to neonatal body weight loss, and sodium homeostasis in 30 full-term newborn infants on the 4th day of life.
Results:
The URO excretion, estimated as URO:creatinine ratio, was significantly correlated to sodium excretion.
Conclusion:
These data show that in full-term newborn infants the mechanisms that control synthesis, excretion and signal transduction of URO are developed and that URO contributes to natriuresis regulation.
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