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Neurological diseases that cause detrusor hyperactivity with impaired contractile function
Tatsuya Yamamoto1, Ryuji Sakakibara, Tomoyuki Uchiyama
1Department of Neurology, Chiba University, Chiba, Japan. tatsuya-yamamoto@mbc.nifty.com
Neurourology and Urodynamics
|March 15, 2006
Summary
Neurological diseases frequently cause detrusor hyperactivity with impaired contractile function (DHIC). This study identifies common neurological conditions linked to DHIC, expanding understanding of its causes.
Area of Science:
- Urology
- Neurology
Background:
- Detrusor hyperactivity with impaired contractile function (DHIC) was initially observed in elderly women.
- The association between neurological diseases and DHIC has not been well established.
Purpose of the Study:
- To investigate which neurological diseases commonly cause DHIC.
- To identify the spectrum of neurological disorders associated with DHIC.
Main Methods:
- A retrospective analysis of 1,514 patient records was conducted.
- Patients were assessed using a lower urinary tract (LUT) symptom questionnaire and urodynamic studies.
- DHIC was defined by detrusor overactivity during storage and underactive contraction during evacuation.
Main Results:
- Two hundred and seventeen patients were diagnosed with DHIC.
- Commonly associated neurological diseases included Parkinsonian syndrome (18%), multiple system atrophy (18%), multiple sclerosis/acute disseminated encephalomyelitis (18%), spinal cord lesions (15%), progressive supranuclear palsy/corticobasal degeneration (14%), multiple cerebral infarction (12%), and cervical spondylotic myelopathy (10%).
- The mean age of patients with DHIC was 63 years.
Conclusions:
- A broad range of neurological disorders can lead to DHIC.
- Neurological conditions are significant contributors to DHIC beyond its initial description in elderly women.